Last Update April 6, 2011

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inferred Protein-Protein Interactions

We have developed a method that predicts Protein-Protein Interactions based on the similarity of the context in which proteins appear in literature [1]. The practical value of the method for discovery of novel PPIs is illustrated by the experimental confirmation of the inferred physical interaction between CAPN3 and PARVB, which was based on frequent co-occurrence of both proteins with concepts like Z-disc, dysferlin, and alpha-actinin. Our framework can be used for prioritizing potential interaction partners, hitherto undiscovered, for follow-up studies and to aid the generation of accurate protein interaction maps. The full set of predicted interactions is available in a downloadable matrix and through the webtool Nermal , which lists the most likely interaction partners for a given protein. Here, we publish the entire compliment of our predicted Protein-Protein Interactions as nanopublications.

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44,000 predicted Protein-Protein Interactions coming soon.

References

  1. Van Haagen et al (2009) Novel protein-protein interactions inferred from literature context, PLoS ONE 4: e7894.